San Andreas already had some support for multiplayer on consoles, so that would have given them somewhere to start with on PC.
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I used SA-MP and later MultiTheftAuto for San Andreas. SA-MP seemed to have the larger user base at the time and there were a lot of deathmatch, freeplay, and roleplay servers. MTA at that time only had vehicular gameplay, meaning you couldn't get out and walk around but this was later added. Of the two mods I think MTA was considered to be better, especially once on foot gameplay was added. The big difference I noted between the two was that SA-MP had horrible desync. You had to lead your shots and other players would take the same amount of damage regardless of whether you shot them in the head or foot. I think there were also lots of internal spats between SA-MP's developers.
This youtube shows the differences between the two that I observed.
This was some years ago, though, so things are probably different now. Oh, and I never had to use Hamachi for either SA mod.
Edit: And since someone always asks, yes, both mods (as well as all other mods) can be used with the Steam version of San Andreas. You just need to first downgrade the Steam version of the game. A simple web search will lead you to the downgrader, but back up your game .exe before using the downgrader.
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