Deleted

"......" -Gordon Freeman
and this, too:
"......" -Chell

We'll bang, ok?

Not quite a quote, but it's pretty common in the game.

• BOOM *
  I added the spaces just to prevent italicization of the effect. The game is McPixel.

,,Real badass eat chocolate-chip-cookies. I will get that tattoed on my back, in old english font"

is the last quote i can remember and thought of it as hilarious.

"Adam, you're there, good, good !"

-David Sarif

This is what it sounds like when doves cry.Though so. ; Hey,didn't I kick your ass two rooms back?! ; Jesus Harold Faltermeyer Christ!What now?! ; Fan-fucking-tastic.Guess I won't be talking to them for a while. ; If war is an art,I am fucking Michaelangelo ;
All from Serious sam 3,Second one is from TSE

Nothing is true, Everything is permitted - Assassin's Creed
Not much of a quote, but it's epic anyway...

"Brothers. Sisters. The whole city rises against us while Yusuf's murderer waits and watches from the arsenal, laughing. Fight with me, and show him what it means to cross the Assassins."
―Ezio, after giving Yusuf his final rites.

Ah... I forgot... "Do you get to the cloud district very often? Oh what am I saying, of course you don’t." - Nazeem

"You jumped into a sword! You retard!"

(which is preceeded by "It's dangerous to go alone! Take this!")

"It's time to kick ass and chew bubble gum, and i'm all outta bubble gum."
and
"Hell, i'd still hit it."

The Duke

"They are coming out of the wall sphincters!"

Stay a while, and listen!

"Minion, what are you doing? Those are human beings, with wives, and families, and...

nah, I'm just kidding! Screw those guys!"

"Did I ever tell you what the definition of insanity is? Insanity is doing the exact... same fucking thing... over and over again, expecting... shit to change. That... is crazy; but the first time somebody told me that...I dunno, I thought they were bullshitting me, so boom — I shot him. The thing is, okay... He was right. And then I started seeing: everywhere I looked, everywhere I looked, all these fucking pricks, everywhere I looked, doing the exact same fucking thing... over and over and over and over again thinking: "This time, it's gonna be different; no, no, no, no, no, please... This time it's gonna be different." ...I am sorry, I don't like the way you are looking at me... Okay, do you have a fucking problem in your head? Do you think I am bullshitting you? Do you think I am lying? Fuck you! Okay? FUCK YOU! It's okay, man. I'm gonna chill, hermano. I'm gonna chill... The thing is... alright, the thing is: I killed you once already... and it's not like I am fucking crazy. It's okay... It's like water under the bridge.
Did I ever tell you the definition... of insanity?"
— Vaas

It's huge!

"Fuck you"

"Rise and shine Mr. Freeman" "Wake up and smell the ashes"

"war. War never changes"

"Would you rather serve in heaven or rule in hell?

don't really know any right now :( but guess where those come from at least haha

"I know you're blind an' all but you've got to see this"

"The numbers Mason,what do they mean?"

when life give you lemons, don't make lemonade. make life, take the lemons back. GET MAAAD.

I WILL BURN YOUR HOUSE DOWN

-> Behold Ragnaros, the Firelord! He who was ancient when this world was young! Bow before him, mortals! Bow before your ending!

<- Too Soon! You have awakened me too soon, Executus! What is the meaning of this intrusion?

-> These mortal infidels, my lord! They have invaded your sanctum, and seek to steal your secrets!

<-FOOL! You allowed these insects to run rampant through the Hallowed Core, and now you lead them to my very lair? You have failed me, Executus! Justice shall be met, indeed!
Now for you, insects. Boldly you sought the power of Ragnaros! Now you shall see it FIRSTHAND!

"HA HA HA HA HA!" - Tidus, Final Fantasy X
"......." - Squall Leonheart, Final Fantasy VIII
"Mother..." - Sephiroth, Final Fantasy VII
“Enough expository banter! Now we fight like men! And ladies! And ladies who dress like men!" - Gilgamesh, Final Fantasy V
“All those who live must some day die. It is our fate.” - Minwu, Final Fantasy II

Ok here comes a long and clever one from one of my favorite games: Sid Meier's Alpha Centauri

We are all aware that the senses can be deceived, the eyes fooled. But how can we be sure our senses are not being deceived at any particular time, or even all the time? Might I just be a brain in a tank somewhere, tricked all my life into believing in the events of this world by some insane computer? And does my life gain or lose meaning based on my reaction to such solipsism?

Project PYRRHO, Specimen 46, Vat 7. Activity recorded M.Y. 2302.22467. (TERMINATION OF SPECIMEN ADVISED)

Note here this game did come out before Matrix so don't say it's ripped of from it!

Bring us the girl, and wipe away the debt.

"A man chooses, a slave obeys"

"..." - Various from Various