Adventure games which are worth playing

If you like the Runaway game you have, you may want to try the other Pendulo games. Like the first two Runaways and The Next Big Thing.
Edit: and Yesterday
In fact I consider A Twist of Fate the weakest Pendulo adventure.

You should try Gabriel Knight series and Sanitarium if you haven't yet. True classics!
Longest Journey, Dreamfall Chapters and Gray Matter are great games as well.

Pretty much anything from Telltale, starting from their Sam & Max series. Their newer ones are less and less interactive, but they still kick some major butt. Also, The Longest Journey series. Maybe Simon the Sorcerer, just don't play any after the third one.

Definitely you must try Broken Sword! Great game, I remember playing it in my childhood.

so many great games. suggesting one is impossibru! -_-

edit: i thought you're seeking for a suggestion which one to play from your game list. sorry for being useless. .-.

You haven't listed them so I think I can suggest them "safely", but since you have a Sam & Max, you could always track down the rest of Telltale's games? There's a Bundle on Steam for them...at the very least I would very highly recommend The Wolf Among Us and the first season of their Walking Dead game...plus they now have a Game Of Thrones game and Tales From The Borderlands but other than that I don't know what to suggest...would you classify Alan Wake as adventure? Deadfall Adventures? The Tomb Raider games?

There was a game back in a day that I really like but it is not on steam called "the moment of silence", it has good plot IMO

Heroine's Quest: The Herald of Ragnarok
Bonus: it's free.

Old ones:
Quest for Glory 3 and 4
Sam and Max: Hit the Road
Leisure Suit Larry 7

Newish ones:
Primordia
The Fall (don't be fooled by the trailer, it's an adventure at heart)
Back to the Future
The Blackwell Series (the first one is kinda like a demo, it gets better and better)
Resonance
Sherlock Holmes vs Jack the Ripper, The Testament of Sherlock Holmes

• The Longest Journey + Dreamfall
• Sam and Max Complete Pack
• The Blackwell Bundle

Toonstruck is one of my all-time favorites

Free (and very good imo) horror adventure games: The Trilby's Series.
Download here. <- of the other games I'll also recommend 1213 (not a point'n'click adventure though)
Order in which to play the Trilby's Series.

Also, the only Myst-like I liked aside from the Myst series: Lighthouse.

nearly every old Sierra game

A lot of games of your non-steam list are actually on Steam.
I've played so many adventure games.... I'm gonna name some I enjoyed and remembered:
(Just use youtube to see what they are about)
No Steam
Cruise for a Corpse
Darkseed
Discworld
Future Wars: Time Travellers
Legend of Kyrandia
Les Manley in Search for the King
Operation Stealth (aka James Bond 007: The Stealth Affair)
Phantasmagoria
Simon the Sorcerer

Steam
A Vampyre Story
Gabriel Knight: Sins of the Fathers 20th Anniversary Edition
Gray Matter
Inherit the Earth
Quest for Infamy
Stranded
The Detail

And basically (almost) all LucasFilm and Sierra games

Post Mortem, Cognition, Flight of the Amazon Queen

The Vanishing of Ethan Carter, a first person adventure with detective puzzles and awesome graphics.

The Telltale games, Wadjet Eye games and the Longest Journey series.

Not sure if the following were mentioned, since I'll check through the thread for suggestions, as well, after I post this, so here you go.

The Raven - Legacy of a Master Thief : Well done mystery/detective adventure game. Reminded me of old games and Agatha Christie novels, a bit.
The Testament of Sherlock Holmes : Haven't played this one yet, but I got it recommended based on the above, so looking forward to playing it myself.
The Last Express : Pretty interesting mystery. The visuals felt odd at first but I got used to them, eventually.
The Dark Eye: Chains of Satinav : Beautiful art/sound, great story and puzzles. The Dark Eye universe is amazing for adventure games, not only for RPGs apparently.
Memoria : Sequel to Chains of Satinav. Loved this one, maybe even more than the first.
The Dracula series : Still have the box copies of two of these. Classic adventure games for me.
Still Life, Still Life 2 : From the makers of Syberia.
The Longest Journey + Dreamfall : Must play games, if you are a fan of the genre. Dreamfall chapters just came out, too.
The blackwell series : Played two out of those so far and looking forward to the rest. Remind me of older titles, a lot.
The Last Door : Played it recently and enjoyed it, though it felt a bit short.
Amerzone : Loved this when I played it years ago. Made by Benoît Sokal, who made other titles like Syberia, Paradise and Sinking Island. I recommend these last two as well. I don't think they are on Steam or where they are sold, considering I bought them on retail.
Atlantis : This along with its sequels (though I didn't like them all as much) where some of my first adventures. I still remember trying to solve all those riddles as a kid. It might be the sentimental value that makes me recommend it but I still think they are worth a play.
Shivah : A bit short but it's worth a play. Same dev as the Blackwell series.
Shadows on the Vatican Act I: Greed : A bit short but it's only the first part, so I guess it's understandable. Quite good otherwise.
Cognition : An Erica Reed thriller : Really enjoyable and with quite logical puzzles.

I haven't played the following but they are on my to play list so thought I'd share :
The Whispered World
The Night of the Rabbit
A New Beginning - Final Cut
The Book of Unwritten Tales
Nicolas Eymerich - The Inquisitor - Book 1 : The Plague
Nostradamus: The Last Prophecy
The Samaritan Paradox

Jack Orlando: Director's Cut

1954 Alcatraz

Basically, all Wadjet Eye's and most Daedalic's games. Runaway series are pretty great too. And lets not forget about classics, I see you've got a nice collection there. Start with the first three Monkey Islands then move to Grim Fandango and Full Throttle, Day of the Tentacle, Beneath a Steel Sky, The Dig, and Loom.

Botanicula and Samorost2 are great games too :)