Civilization 5 seems like the obvious choice here.
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If you like something squadbased you can play Xenonauts (or the older xcom like games), the classic Silent Storm, or the rpg showrun returns. Also something indie, Banner Saga.
In the line of the Europa Universalis, you could try the Victoria games.
On the line of Rome, try Shogun 2, that one is pretty good.
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Galactic Civilizations, Rise of Nations, Sins of a Solar Empire, Age of Empires
Heard Endless Space is sort of 50/50
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World in Conflict. Highly underrated, but awesome as all hell.
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Some stuff similar to Rome Total War, Mount and Blade Warband, Europa Universalis and the like.
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