THE OLD WEST, 1864. In order to save their family, the McCall brothers will kill anyone who stands between them and the legendary Gold of Juarez. But when the allure of women and money tests their bond as brothers, will the blood they share prove to be thicker?

According to its creators Call of Juarez: Bound in Blood was aimed to make the player's experience as the "best West ever created". The game derives from spaghetti-western genre: gunslingers, outlaws, duels, prison breaks, bank robberies, stagecoach chases and conflicts with Native Americans, similar to another western game, Gun. It features two characters, brothers Ray and Thomas. The game plot is set in the American Civil War period and presents the adventures of two brothers across different parts of North America. Call of Juarez: Bound in Blood is the second installment in the Call of Juarez series.