Calcu-Late is a story about a boy named James that needs to participate in a godly Olympics tournament as a representative for the goddess of mathematics, Seshat. The tournament will grant the participant a wish that they stated before the tournament starts.

The game is made up of stages, with a puzzle on each stage and story cut-scenes in between. The game has auto-save feature in each stage so if you failed in a certain puzzle, you can try again by clicking continue.

On every stage there will be a trial phase and a battle phase. In the trial phase, the player will be given a puzzle that can be solved alone by thinking or calculating. In the next phase, which is the battle phase, the player will have a match against the AI. Battles require concentration and patience.