I think the game can be played independently. The two scientists (or doctors, maybe) are from To the Moon, but the main premise of these stories is having the dying person achieve an ambition or goal. So the real heart of the story involves the dying person, their past life, the people from their life and whatever mystery journey they want at the end. I have only played To the Moon, but loved it. This should be a good story rich game too. Hope you enjoy it.