"I'm glad Garrus finally worked that stick out of his ass... But now he's trying to beat people to death with it."
-Flight Lieutenant Jeff 'Joker' Moreau

The last time i drank something facing towards my monitor -.-

Nyx,nyx,nyx,nyx

"Too many people have opinions on things they known nothing about. And the more ignorant they are, the more opinions they have"

"The liberation of Rome has began!" - Ezio Auditore (Assassin's Creed Brotherhood)

"I'm Batman" can't remember what game it's from.

Hindo's...DOOOOOOOOOOOOOOOOOOOOOOOOOOOM!

Cracks me up every time

FINISH HIM! [Mortal Kombat 1-infinite]

GET OVER HERE! [Scorpion]

''Nom Nom Nom'' Gentleman Chogath [League of Legends]

The Postal Dude: You probably thought you weren't gonna die today? Surprise! [Postal 2]

Obviously not a SF2 Quote :)

Too late...friends. Nefarius' corruption has taken hold. I cannot...control myself. I beg you Mortals, flee! Flee before I lose all sense of control. The Black Fire rages within my heart. I must release it! FLAME! DEATH! DESTRUCTION! COWER MORTALS BEFORE THE WRATH OF LORD....NO! I MUST FIGHT THIS! ALEXSTRASZA, HELP ME! I MUST FIGHT!" - Vaelastrasz [World of Warcraft]

"The Enrichment Center reminds you that the Companion Cube will never threaten to stab you and, in fact, cannot speak. In the event that the Companion Cube does speak, the Enrichment Center urges you to disregard its advice." - Portal

• Running is like walking, only faster. Far Cry Blood Dragon tutorial
• Don't you recognize me? It's a-me, Mario! Assassin's Creed 2

Leisure suit larry : "you know what would look good on you ? Me !"
spiderman 2 : "Tony hawks j'ai fait du skate avec lui !" <= reference to tony hawks pro skater 2 where we could play as spiderman character :D
final fantasy 10 : "Story of my life" ... i just loved how he said it :D

All you base are belong to us.

“All we had to do was follow the damn Train, CJ!”

I'm surprised that nobody posted this one :P waiting for +1

"Life is like a box of ammo"

Ok....let´s do the boring part, but someone has to do it:

I used to be an adventurer like you, but then....

War is when the young and stupid are tricked by the old and bitter into killing each other. Niko Bellic - Grand Theft Auto IV

Aww,here,here's a good one.Hey, do you know the difference between sex and conversation? No? You wanna go back to my place and talk?
Joe Barbaro-Mafia II

"Names are for friends...so I don't need one." -Agent 47
"Your memes end here" -Raiden
"..." -Gordon Freeman

"Dear Helena,

By now, the news of our defeat has reached the Earth.
The creatures we were sent here to tame are un-tamable
and the colonies we were sent to reclaim have proven to be stronger than we anticipated.
Whatever you may hear about what has happened out here, know this:
Alexey did not die a hero.
I killed him. My pride killed him.
And now my pride has consumed me as well.
You will never see me again, Helena.
Tell our children that I love them,
and that their father died in defense of their future.

Au revoir."

• General DuGalle's final message to his wife
  StarCraft: Brood Wars

"You fight like a cow" -The Secret of Monkey Island

View attached image.

"Mess with the best, you will die like the rest" Duke Nukem
"Got a present for ya!", "Real tough guy!" and "That was left handed!" GDI commando from the original command & conquer
"A little C4 knocking at your door." Chrono Commando from Red Alert 2.
"Pathetic creature" Slayer Knight in the warlords battlecry games.
"Communism is the very definition of failure!" Liberty Prime

The Witcher 2: "A whole will never bite another whore." Henselt,
Company of Heroes 2: "You can count on Osttrupen... No, really you can!" Osttruppen (the worst and cheapest unit)

"I fucking hate tutorials." - Sergeant Rex "Power" Colt

"Tell me Doctor Freeman if you can, you have destroyed so much, what is it exactly that you have created? Can you even name one thing? I thought not..." Wallace Breen, Half-life 2

"The right man in the wrong place can make all the diffrence in the world" G-Man, Half-life 2

"Thank you for helping us help you help us all" GLaDOS, Portal

"Heresy grows from idleness" Space Marine unit, W40K: Dawn of War

"That's Mushy Snugglebites' badonkadonk. She's my main squeeze. Lady's got a gut fulla' dynamite and a booty like POOOW!"

-Tiny Tina - Borderlands 2