While playing a game, normally the tunes I love the most are the saddest ones, so I'd like to hear your favorite ones under this category. Also an explanation of what happens in the game that makes it so depressing would be appreciated.

SPOILER ALERT, please write the name of the game first to avoid spoiling it, as sure most of them will involve character's deaths.

Mines are:

-Final Fantasy XIII: Dust to dust. Two members of your party have been dormant for centuries in a distant world. When they finally get back to their home, they find a devastated town and its population turned into monsters.

-Final Fantasy XIII-2: Noel's theme/The last travel. This character lives in the future, when almost all mankind has disappeared and only three people are left. His friend and mentor leaves his world to find a way to save his other friend, a little girl victim of a curse that dies shortly after his departure, leaving him all alone in that devastated world.

-Metal Gear Solid 3 Snake Eater: Debriefing. You are forced to kill your mentor, a national hero that has betrayed you and your country and allied with the enemy. After you finally kill her, you find out that everything was just a set up made by the goverment to steal a huge amount of money from the enemy faking the defection of your mentor. When something unexpected puts the plan in danger, she is forced to sacrifice herself in order to keep your country's name clean, while she will be remembered as a monster. Hearing this tune with the ending speech brings tears to my eyes.

TL.DR: just post the damn songs.