How to avoid any kind of country restriction on Humble bundle?

Great deal

It's based on IP address right now, as far as I know, since they distribute keys, and activation restriction on Steam keys is based on IP address as well.

(Btw, you can edit the category of this post to General, since Deals section is displayed on the main page to inform of current deals)

Yes, it is bypassable by VPN, but it is violation of their Terms and therefore you can get banned.

Is there a difference between region lock and country restriction because it seems like the country restrictions in the November bundle are based on US trade restrictions, so wouldn't that be different from a key being only redeemable in a region like Europe or Africa due the purchased being made there?

I do this all the time with no problems so I can say with utmost confidence on what I'm about to say:

You get your region locked based on the purchaser's region at the time of purchase IF you are being given giftlinks of individual games. HOWEVER you get your region locked based on the redeemer's region at the time of redemption IF you are being gifted the entire monthly.

Quote taken from the HB support article: https://support.humblebundle.com/hc/en-us/articles/202712460-Purchasing-and-Sending-Gifts#partial

NOTE: All purchases made on your account, whether personal purchase or gift purchase, will be tied to your region. This means that any region locked keys may not work if your friend lives in a different region! When using the "Gift to a friend" option you will see a pop up warning displaying pertinent information.

The only exception to this would be if you purchased a gift monthly subscription for a friend. In this instance, your friend would receive keys assigned to their region upon redeeming the gift.