Most meaningful video games?

Thomas was alone.

Warcraft and Starcraft series!!

Bioshock and Bioshock Infinite(NOT Bioshock 2), World In Conflict, S.T.A.L.K.E.R. - Shadow of Chernobyl, Metro 2033, Metro - Last Light, Unreal 2 The Awakening, Grand Theft Auto IV, Spec Ops The Line, The Prince of Persia original trilogy, Dead Space 2, Deus Ex and Deus Ex Human Revolution, Mass Effect(only the first one because it actually touches the theme of friendship in a sci-fi universe just like Unreal 2 and doesn't have any war and Starship Troopers heroism bullshit, like the other 2), the entire Max Payne series, The Suffering series(a personal experience delving into the human mind), Far Cry 3, Tomb Raider(2013) and there may be some others I missed. Anyhow, bottom line is there's tons to choose from.

theBioshock games have that meaningful thing, not too much, but is there. do you want to harvest those little monsters? or are you going to spare their lives? does it even matter? aren't they just monsters? is right to feel like shit when you murder their "daddy"? because, let's be honest, they never attack you unless you attack first, but you need the adam... no, you WANT the adam, you want the power...

i experience the same on Fallout: New vegas. specially with The Lonesome Road DLC.
those kind of games that give you some sort of freedom. sure, you can go on a killing spree, and murder every single thing you see, but do you really want to do that? would you spare the live of those who are bad?, would you help them if they need your help? or would you kill every last of them?
if you kill them, you will save those poor villagers, and if you don't they probably are going to kill everyone, or worst. you have to decide. kill the bad guys, do nothing. or join them and loot everything, hell, you can even join the bad guys, and then murder them.

other meaningful are probably games like rust and DayZ... but just because they show you how humanity sucks. like this little example from RPS (relax, not a "your sex is wrong" kind of article)

http://www.kotaku.com.br/a-sutileza-de-the-binding-of-isaac/ if you can read portuguese, read this

Silent Hill 2

The Plan (and it takes less than 10 minutes to complete!)

Final fantasy tactic, both the psx and gameboyadvance

PC:
To The Moon: Just play this. Please, play it.
Portal 2: The take on conscience as something made by someone else other than you. Morality cores and shit.
Home: This one is pretty interesting. Makes you question everything as a whole.

A bonus for the PS2:
Kingdom Hearts I and II: They made me think about the darkness in our hearts, and that if there is someone terribly dark, that person has a strong heart, but towards the wrong path. And when you DO give in to the darkness that exists in you, you DO become a different person, either a monster or a shell, and they both hurt the ones around you. Also, when people truly share a common goal, they forge incredibly strong bonds that will keep them together for good.

Xenogears

I'm playing Bastion and loving it, it's almost made me cry. Spec Ops was also really good, and I like Braid.

cal a dooty

Dear Esther.

flappy bird

Bad Rats, really broke my heart when I found out that there is no sequel. I tried to commit suicide but that didn't work because I'm immortal. pls help

First thing I thought of was To The Moon. Deals a lot with morality and ethics. Very powerful game.

Everyone mentions Bioshock... But they forget the Original(s) System Shock and System Shock 2.

You don't want to miss Lost Odyssey. I know its for Xbox, not sure if there is a PC version.
This game made my cry many times, lol.

Have a nice day and good luck :)

Fallout 1, 2, 3 and NV
Consequences of your choices.
Also many meaningful events.

BioShock 1-2, Bastion, Dishonored

Super hexagon.

Walking dead

Minesweeper.

Seriously, though, the Xuan Yuan Sword series.

Th only game I can possibly think of to fill this would be Spec Ops: The Line.

Metal Gear Solid: Peace Walker :3