King's Quest is really good if you don't mind that the games are very old and you'll likely need a guide for them because the puzzles do get hard.
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Others have suggested it already, but I also say Botanicula. It's a cute/interesting game.
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Day of the Tentacle
Monkey Island series
Sam & Max series
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I enjoy playing "point-and-click" adventure* games.
One I like a lot is Edna and Harvey: Harvey's New Eyes.
What are some of your favorite/recommended point-and-click games?
*edit - notnsane
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