What are the best games to only play with a mouse? Like point and click

Fallout 1-2. Diablo 1-2. Just about any old-school dungeon crawler, RTS games - (I'd suggest Empire Earth, Warlords Battlecry III, and Rise of Nations), ANY point-and-click adventure title (http://www.adventuregamers.com/ has a good majority of reviews for these, to help you pick out one you may like) - Deponia and Chaos on Deponia are both great, similar in style to the Monkey Island series.

Chalk

Deponia :D

Um, Baldurs Gate?

Go play osu! :P

Audiosurf

The Ben Jordan: Paranormal Investigator series. (Almost no keyboard use.)

Solitaire, minesweeper, freecell ;p

How has no one mentioned The Cave yet?!

Here's a good list of the best games made for the cursor I've ever played. (#1 requires more than a mouse, so skip it.)

Jamestown

Runescape, obviously.

Grand Strategy games. Europa Universalis, Victoria, Crusader Kings, Hearts of Iron, etc.

Also, King's Bounty.

10,000,000

You might try Atom Zombie Smasher, keyboard is not going to be needed but it may help a bit.

Auditorium, Critical Mass, Lucid

Any fps.

Heroes of Might & Magic are playable with mouse only. Clash of Heroes is great too.
You can play Don't Starve with mouse only, but I prefer WSAD + space + mouse. It's much easier to play.

Ultima VII (Parts 1 & 2) and Ultima VIII - Need DosBox

Full Throttle - Need SCUMM

Civilization V & Civilization V Gods & Kings
It has win 8 mode which can be fully operated with touch (or mouse)

Puzzle Quest 1 & 2

X-COM: Ufo Defense

X-COM: Terror from the Deep

XCOM: Enemy Unknown

Fallout

Fallout 2

Only ONE person mentioned The Longest Journey!? I'm deeply saddened by this :(

commandos series

Don't Starve.