Looking for good English Dubbed Anime featuring girls as main characters?

Bible Black :p

If you can find it, and you're okay with androids, Big O. It even has giant robots, if that floats your boat, though it's not very much like lucky star.

I haven't watched any anime with subs, I have enjoyed a lot of it that was dubbed though. I must have been lucky to find the "good ones" I guess, because I never once thought it was a crappy job they did in the translation. Rosario+Vampire, Death Note, Monster, D. Gray man, Soul Eater, and Requiem from the Darkness come to mind as a few of my favorites.

Ouran High School Host Club. It's about a poor person who gets accepted into a rich school, filled with beautiful girls and beautiful boys. It's also rather hilarious, and not something that I expected to like, me being a guy (even my sister was surprised that I liked it so much). The interactions between the character make the series (and especially the manga) fantastic.

It's available in subbed and dubbed versions here (scroll down to the fansubbing section for download links).

Is Saki dupped?

While I greatly prefer sub to dub, I'm not going to hate on your preferences. To each his (or her) own, after all.

Samurai Champloo and Sekirei both had decent dubs. You might also consider Air Gear if you don't mind an unfinished series. (I'm still sad there's no sequel.)

High School DxD

Appleseed

LAIN

Fushigi Yugi

Ghost in the Shell (any and all)

Kiddy Grade

Magic Knight: Rayearth

Patlabor (my personal favorite anime of all time)

Someday's Dreamer is a cute short series

Twelve Kingdoms (long but very good)

With Hunter Robin

Soul Eater

I'm sure I could name many more, but going through the list I own, that's what I came up with.

Bubblegum Crisis : Tokyo 2040

Mushi-shi has a good dub. FMA:Brotherhood has a pretty good dub too.

For female mains I really liked Moribito, but the dub isn't very good.

I really liked Read or Die. There's the TV series, R.o.D. The TV and the OVA movie. Here's a link to episode 1 I googled.

http://www.dailymotion.com/video/xtqnn_read-or-die-episode-1_fun

Find a funimation dub with a female main character. Funimation has the best voice actors ever

At the risk of ... the hell with it. Anyone saying that English dub is better than Japanese original voice acting is crazy. Japan has an entire industry dedicated to voice acting. It isn't even close.

My recommendation to the OP is to learn how to read faster. Original Japanese voice acting with English subs is far superior to English dub. I'm all for differing opinions, but this ... this is not even debatable.

baccano

mushishi

full metal alchemist.

School Rumble

Gun x Sword