What are your favorite games that can be played one handed?

Some (or most) of these were already mentioned, but some good games which I played and liked and can be played with one hand:

I would advise a Turn-based Strategy game, like Heroes of Might & Magic III (or any other from the series). (The Complete Edition is on GoG and the HD version is on Steam. The HD doesn't have the expansions.) Or Sid Meier's Civilization V.
Or maybe a Visual Novel, like Steins;Gate.
There are some Real-Time Strategy games which don't require hotkeys like Tropico 4 (or any other from the series) or Plague Inc: Evolved. Or GemCraft - Chasing Shadows just keep your mouse on the pause button just in case.
You could try a Puzzle game, like Glass Masquerade or The Room.
And also there are some good RPGs like Sid Meier's Pirates! or some RPG Maker games.

Edit: I see you've already completed Glass Masquerade. (But since then it got a new dlc.)

turn-based games like Civilizations V / VI, XCOM 2

also ETS 2 / ATS

Northgard

Probably Guild of Dungeoneering, it should be able to be played one handed.

I'm sorry to hear about your hand, YuriDiculous. I hope it will heal soon.

As to games: turn-based RPG's and strategy games should be playable one-handed, some just have better UI than others.

Those endless runner/jump games, like geometry dash perhaps even melody's escape.
Audiosurf is fun too

Also, dang, sorry about your hand, hopefully it will heal nicely

I just finished The Pillar of the Earth and i reaaaaaaaally love the story. It is a point&click game but i really had fun.

And I was so sure this would be an x-rated thread.

My favorite one-handed game is Letter Quest.

Don't starve.
If you like the first fallout, I can recommend Arcanum.

https://store.steampowered.com/app/4800/Heroes_of_Annihilated_Empires/ old but gold

Sorry about your hand, hopefully it'll heal soon. I wonder if you'll have success with Telltale games since they still do require bit of coordination between keyboard and mouse, but not that extensively so you might manage.

If you just want to waste time without any point to it, go for The Sims. Otherwise here's some suggestions:
The Descendant
From Dust
Gemini Rue
Orwell: Keeping an Eye on You
Papers, please
Simulacra
This War of Mine

how do you crush your hands with pins aren't those small

any RTS game like age of empires saga for example
Xcom games
even some final fantasy games (ff 8 or ff7 for example)
one finger death punch 1 and 2
grim dawn
divinity original sin
castlestorm
blackguards 1 and 2 (really nice games!!!)
anno 1404 or any other anno saga game
100% orange juice
skulls of the shogun
miracle fly
fallen enchantress: legendary heroes

Damn, that's tough. I hope it heals well D:

A lot of strategy and turn-based games are easy on the hands. I probably played all of Fire Emblem one-handed, for example. Not for the anime girls, I swear :P

Probably not the answer you're looking for, but I used to co-op with my fam where one of us would take the keyboard and the other take the mouse and we'd clear games like that together. Did that with Bioshock Infinite, Mass Effect, Tomb Raider... it's pretty fun if you've got good company.

Crypt of the NecroDancer

Sorry to hear about your hand... I hope you'll be fine soon!
As for the games... I remember playing Final Fantasy games (^^ the important part is that the fights are turn-based) with just one hand, so a lot of turnbased or strategy games should work. Basically everything where you have time to plan your moves.
City builders also come to mind, along with a good amount of puzzle games.

I'm sorry if the games I'm going to link won't be exactly your cup of tea ._. But who knows, maybe one of them will be interesting ^^

Fell Seal: Arbiter's Mark is a lovely tactical RPG and you shouls be able to play it with a mouse only.

Muse Dash might not be your cup of tea ^^" but hinestly, the music is catchy, the visual are cute and the controlls consist of two buttons (and are customizable).

Sigma Theory: Global Cold War should be playable with mouse only and is, in my opinion, a fun game. I never mnanaged to win, but it was always a great experience!

Domina is great. You train your Gladiators, bribe the Magitrat and Legat to favour you and the only thing you would need your second hand is to controll your Gladiators in battle (and I would not recommend it x.x they are fine on their own, probably even better then when controlled by the player).

Knights of Pen and Paper +1 Edition as well as the other "Pen and Paper" games are, as far as I know, all playable with one hand and really a ton of fun :D

And although I know that you don't like point & click games, I still want to recommend you Deponia: The Complete Journey. It's funny, clever, deeper than you might think and overall a great game (or rather a trilogy)!

Civilization VI

Sorry to hear about your hand.
Hope you get better soon.

You did said that you don't like point and click games. But how about puzzle games?
Pixel puzzle series,
Ubinota,
LYNE
Deponia
etc

And not to mention visual novels too.

Also this action games can be played 1 handed too
Iron Snout

Civ VI

You could play one of the old on-rails shooters.

FTL or Plants vs. Zombies. They both do their own thing well, so I can't choose.

Everyone already named every game I could think of lol But I hope your hand heals up quickly :)

Hope you get well soon!

Meanwhile some games that nobody mentioned (I THINK):

World of GOO
https://store.steampowered.com/app/22000/World_of_Goo/

Desktop Dungeons (amazing, addicting, time consuming, and amazing again)
https://store.steampowered.com/app/226620/Desktop_Dungeons/

Diablo 1 (I think is very methodical and playable with one hand, maybe not Hellfire that is faster paced)
https://www.gog.com/game/diablo

Phoenix Wright Ace Attorney
https://store.steampowered.com/app/787480/Phoenix_Wright_Ace_Attorney_Trilogy__123/

Turn-based RPGs can be a good choice, sure. So, Divinity: Original Sin 1-2, The Banner Saga 1-3, Shadowrun trilogy, Torment: Tides of Numenera, The Age of Decadence, Expeditions: Conquistador & Expeditions: Viking, Ash of Gods: Redemption. Pillars of Eternity II: Deadfire has got a turn-based mode recently (haven't tried it yet though).